Achievement
研究実績

原著・英文総説

2024

  1. Shigetomi E, Suzuki H, Hirayama YJ, Sano F, Nagai Y, Yoshihara K, Koga K, Tateoka T, Yoshioka H, Shinozaki Y, Kinouchi, H, Tanaka KF, Bito H, Tsuda M, Koizumi S. Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. Nat Commun, 15(1):6525. doi: 10.1038/s41467-024-50190-7. 【Press Release】Media report

  2. 2023 US-Japan NVU Workshop Group. From bench to bedside: US-Japan Collaborative Workshop on the NVU. J Physiol Sci. ;74:31. doi: 10.1186/s12576-024-00917-4. (2024)

  3. Parajuli B, Koizumi S. Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia. Purinergic Signalling, https://doi.org/10.1007/s11302-024-10014-1. Online ahead of print. (2024)

  4. Hirayama Y, Le PN H, Hashimoto H, Ishii I, Koizumi S, Anzai N. Preconditioning-induced facilitation of lactate release from astrocytes is essential for brain ischemic tolerance. eNeuro, ENEURO.0494-23.2024; doi: 10.1523/ENEURO.0494-23.2024. Online ahead of print. (2024)

  5. Dewa K, Arimura N, Kakegawa W, Itoh M, Adachi T, Miyashita S, Inoue U Y, Hizawa K, Hori K, Honjoya N, Yagishita H, Yaya S, Miyazaki T, Usui C, Tatsumoto S, Tsuzuki A, Uetake H, Sakai K, Yamakawa K, Sasaki T, Nagai J, Kawaguchi Y, Sone M, Inoue T, Go Y, Ichinohe N, Kaibuchi K, Watanabe M, Koizumi S, Yuzaki M, Hoshino M. Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation. Nat Commun, 15, 458. https://doi.org/10.1038/s41467-023-44579-z. (2024)

  6. Saito K, Shigetomi E, Shinozaki Y, Kobayashi K, Parajuri B, Kubota Y, Sakai K, Miyakawa M, Horiuchi H, Nabekura J, Koizumi S. Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model. Brain. 147(2): 698-716. doi: 10.1093/brain/awad358. (2024) 【Press Release】Media report

  7. Shigetomi E, Sakai K, Koizumi S. Extracellular ATP/adenosine dynamics in the brain and its role in health and disease. Front. Cell Dev. Biol. 11:1343653. doi: 10.3389/fcell.2023.1343653(2024)

2023

  1. Le Y-P, Saito K, Parajuli B, Sakai K, Kubota Y, Miyakawa M, Shinozaki Y, Shigetomi E, Koizumi S. Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms. Int. J. Mol. Sci. 24, 17597. https://doi.org/10.3390/ijms242417597 (2023) 

  2. Ihara T, Shinozaki Y, Shigetomi E, Danjo Y, Tsuchiya S, Kanda M, Kamiyama M, Takeda M, Koizumi S, Mitsui T. G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders. Life Sci. :332:122072. doi: 10.1016/j.lfs.2023.122072.(2023)

  3. Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, Mori Y, Kaneko S, Shirakawa H. The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production. Sci. Adv. 9(29):eadh0102,  doi: 10.1126/sciadv.adh0102. (2023) 

  4. Shinozaki Y, Kashiwagi K, Koizumi S. Astrocyte Immune Functions and Glaucoma. Int J Mol Sci, 24(3):2747. doi: 10.3390/ijms24032747.(2023)

  5. Ono T, Yamashita T, Kano R, Inoue M, Okada S, Kano K, Koizumi S, Iwabuchi K, Hirabayashi Y, Matsuo I, Nakashima Y, Kamiguchi H, Kohro Y, *Tsuda M. GPR55 contributes to neutrophil recruitment and pain induction after spinal cord compression in mice. Brain, Behavior and Immunity, 110 276-287. Doi:10.1016/j.bbi.2023.03.008. (2023) 

     

  6. Saito K, Koizumi S. A promising drug for neuropathic pain: identification of vesicular nucleotide transporter as a novel target of eicosapentaenoic acid. Purinergic Signal, 19(4):587-589. doi: 10.1007/s11302-022-09918-7. (2023)

2022

  1. Shinozaki Y, Saito K, Kashiwagi K, Koizumi S. Ocular P2 receptors and glaucoma. Neuropharmacology, 222:109302. doi: 10.1016/j.neuropharm.2022.109302.Epub 2022 Oct 30. (2022)

  2. Shinozaki Y, Leung A, Namekata K, Saitoh S, Nguyen HB, Takeda A, Danjo Y, Morizawa YM, Shigetomi E, Sano F, Yoshioka N, Takebayashi H, Ohno N, Segawa T, Miyake K, Kashiwagi K, Harada T, Ohnuma S, Koizumi S. Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy. Sci Adv, 8(44):eabq1081.  doi: 10.1126/sciadv.abq1081. Epub 2022 Nov 4(2022) 【Press Release】

  3. Morizawa YM, Matsumoto M, Nakashima Y, Endo N, Aida T, Ishikane H, Beppu K, Moritoh S, Inada H, Osumi N, Shigetomi E, Koizumi S, Yang G, Hirai H, Tanaka K, Tanaka KF, Ohno N, Fukazawa Y, Matsui K. Synaptic pruning through glial synapse engulfment upon motor learning. Nat Neurosci, 25(11):1458-1469. doi: 10.1038/s41593-022-01184-5. Epub 2022 Nov 1. (2022) 

  4. Shigetomi E, Koizumi S. The role of astrocytes in behaviors related to emotion and motivation. Neurosci Res;187:21-39,  doi: 10.1016/j.neures.2022.09.015. (2022) 

  5. Parajuli B, Koizumi S. Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain. Neurochem Res, 48(4):1066-1076. doi: 10.1007/s11064-022-03742-6. (2022)

  6. Shimozono K, Nan H, Hata T, Saito K, Kim Y-J, Nagatomo H, Ohtsuka T, Koizumi S and Takiyama Y. Ubap1 knock-in mice reproduced the phenotype of SPG80. J Human Genetics, 67, 679–686, doi: 10.1038/s10038-022-01073-6. (2022)

  7. Manita S, Sgigetomi E, Bito H, Koizumi S, Kitamura K. In Vivo Wide-Field and Two-Photon Calcium Imageng from a Mouse using a Large Cranial Window. J. Vis. Exp, (186), e64224, doi:10.3791/64224 (2022)

  8. Koizumi S, Hirayama Y. Ischemic Tolerance Induced by Glial Cells. Neurochem Res, 47(9):2522-2528. doi: 10.1007/s11064-022-03704-y. (2022)

  9. Takeda I, Yoshihara K, Cheung DL, Kobayashi T, Agetsuma M, Tsuda M, Eto K, Koizumi S, Wake H, Moorhouse AJ and Nabekura J. Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour. Nat Commun, 13(1):4100. doi: 10.1038/s41467-022-31773-8. (2022)

  10. Hirayama Y, Anzai N, Kinouchi, H and *Koizumi S. P2X7 receptors in astrocytes; as a switch for ischemic tolerance. Molecules, 27(12):3655.  (2022)

  11. Parajuli B, Shinozaki Y, Shigetomi E and *Koizumi S. Transplantation of Human Induced Pluripotent Stem Cell-derived Microglia in Immunocompetent Mice Brain via Non-invasive Transnasal Route. J Vis Exp, 183, e63574. (2022) 

  12. Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J and *Koizumi S. Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice. J Exp Med, 219 (4): e20210989.(2022) 【Press Release】Media report

  13. Ihara T, Shimura H, Tsuchiya S, Kanda M, Kira S, Sawada N, Takeda M, Mitsui T, Shigetomi E, Shinozaki Y, Koizumi S.  Effects of fatty acid metabolites on nocturia. Sci Rep. 12(1):3050.(2022)

  14. Danjo Y, Shinozaki Y, Natsubori A, Kubota Y, Kashiwagi K, Tanaka KF and *Koizumi S. The Mlc1 promotor directs Müller cell-specific gene expression in the retina. TVST, 11(1), 25. doi: 10.1167/tvst.11.1.25. (2022) 

  15. Koizumi S. Glial Purinergic Signals and Psychiatric Disorders. Front. Cell. Neurosci, 15:822614. doi: 10.3389/fncel.2021.822614. eCollection 2021. (2022)

  16. *Konishi H, *Koizumi S and *Kiyama H. Phagocytic astrocytes: emerging from the shadows of microglia. GLIA,70(6):1009-1026. doi: 10.1002/glia.24145.  (*co-correspondence)(2022) 

2021

  1. Koizumi S, Shigetomi E, Sano F, Saito K, Kim SK, Nabekura J. Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases. Int.J.Mol. Sci, 23, 149. https://doi.org/10.3390/ijms23010149. (2021)

  2.  

2020

2019

2018

2017

2016

  1. Mizuno, K., Shibata, K., Komatsu, R., Omiya, Y., Kase, Y. Koizumi, S. An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy; combination therapy with Goshajinkigan and Busi. Cancer Biol Ther., 17(11):1206-1212. (2016)

2015

2014

2013

    • Imura, Y., Morizawa, Y., Komatsu, R., Shibata, K., Shinozaki, Y., Kasai,H., Moriishi, K., Moriyama, Y. and Koizumi S. Microglia release ATP by exocytosis. Glia., 61(8):1320-1330. (2013)

2012

  1. Suyama, S., Sunabori, T., Kanki, H., Sawamoto, K., Gachet, C., Koizumi, S. and Okano, H. Purinergic signaling promotes proliferation of adult mouse subventricular zone cells. J. Neurosci., 32: 9238-9247. (2012)

  2. Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J. Clin. Invest., 122:722-732. (2012)

2011

    • Koizumi, S. A new role of astrocytes. Japanese Journal of Neurosurgery, 20, 552-558. (2011)

2010

    • Koizumi, S. Synchronized Ca2+ oscillations in astrocytes. FEBS J. 277, 286-292.(2010) .

2009

    • Inoue, K., Koizumi, S., Kataoka, A., Tozaki-Saito, H. Tsuda, M. P2Y6-evoked microglial phagocytosis.International Review of Neurobiology, 85, 159-163. (2009)

2008

2007

  1. Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Tozaki-Saitoh, H., Yoshimura, M., Koizumi, S., Shimizu, T., Inoue, K. Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. J. Neurochem., 102(5):1658-1668. (2007)

  2. Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B.V., Jacobson, K.A., Kohsaka, S., Inoue, K. UDP acting at P2Y6 receptors is a novel mediator of microglial phagocytosis. Nature., 446(7139):1091-1095. (2007)

2006年以前の原著・英文総説はこちら

  • グリア
  • Glia
  • ニューロン
  • Neuron
  • 脳疾患・眼疾患
  • Brain diseases・Eye diseases

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