Achievement
研究実績

原著・英文総説（2006年以前）

2006

  1. Shinozaki, T., Koizumi, S., Ohno, T., Nagao, T., Inoue, K. Activation of P2Y1 receptors in astrocytes interferes the H2O2-evoked death promoting signaling cascades. Glia, 54, :606-618. (2006)

  2. Tozaki-Saito, H., Koizumi, S., Sato, Y., Tsuda, M., Nagao, T., Inoue, K. Retinoic acids increase P2X2 receptor expression through the 5’-flanking region of P2rx2 gene in rat phaeochromocytoma PC12 cells. Mol. Pharmacol, 70, 319-328. (2006)

  3. Nasu-Tada, K. *, Koizumi, S.*, Tsuda, M.*, Kunifusa, E., Inoue, K. Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia. Glia, 53, 769-775. (*equal contribution) (2006)

  4. Fujishita, K., Koizumi, S., Inoue, K. Upregulation of P2Y2 receptors by retinoids in normal human epidermal keratinocytes. Purinergic Signal, 2, 491-498. (2006)

2005

  3. Nasu-tada, K., Koizumi, S., Inoue, K. Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin:different regulations by ADP through PKA. Glia, 52, 98-107. (2005)

  4. Narita, M., Miyatake, M., Shibasaki, M., Tsuda, M., Koizumi, S., Narita, M., Yajima, Y., Inoue, K. Suzuki, T. Long-lasting change in brain dynamics induced by methamphetamine: enhancement of protein kinase C-dependent astrocytic response and behabioral sensitization. J. Neurochem., 93, 1383-1392.(2005)

  5. Inoue, K., Denda, M., Tozaki, H., Fujishita, K., Koizumi, S., Inoue, K. Characterization of multiple P2X receptors in cultured normal human epidermal keratinocytes. J. Invest. Dermatol., 124, (2005)

  6. Shinozaki, Y., Koizumi, S., Ishida, S., Sawada, J., Ohno, Y., Inoue, K. Cytoprotection against oxidative-stress-induced damage of astrocytes by extracellular ATP via P2Y1 receptors. Glia, 49, 288-300.(2005)

2004

  2. Koizumi, S., Fujishita, K., Inoue, K., Shigemoto-Mogami, Y., Tsuda, M., Inoue, K. Ca2+ waves in keratinocytes are transmitted to sensory neurons; involvement of extracellular ATP and activation of P2Y2 receptors. Biochem J, 380, 329-338. (2004)

  3. Inoue, K., Tsuda, M., Koizumi, S. ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Chronic Pain and Microglia: Involvement of the ATP Receptor P2X4. J. Pharmacol. Sci., 94, 112-114. (2004)

  4. Tsuda, M., Mizokoshi, A., Shigemoto-Mogami, Y., Koizumi, Kohsaka, S., Inoue, K. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia, 45, 89-95.(2004)

2003

  1. Inoue K, Koizumi S, Tsuda M, Shigemoto-Mogami Y Signaling of ATP receptors in glia-neuron interaction and pain. Life Sci, 74, 189-197. (2003)

  2. Koizumi S., Fujishita K., Tsuda M., Shigemoto-Mogami, Y., Inoue K. Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc.Natl.Acad.Sci.USA, 100, 11023-11028. (2003)

  4. Inoue, K., Tsuda, M., Koizumi, S. ATP induced three types of pain behaviors, including allodynia. Drug Development Research, 59, 56-63. (2003)

  5. Koizumi, S., Fujishita, K., Tsuda, M., Inoue, K. Neuron-to-astrocyte communication by endogenous ATP in mixed culture of rat hippocampal neurons and astrocytes. Drug Development Research, 59, 88-94. (2003)

2002

  1. Koizumi, S., Saito, Y., Nakazawa, K., Nakajima, K., Sawada, J. Kohsaka, S., Illes, P., Inoue, K. Spatial and temporal aspects of Ca2+ signaling mediated by P2Y receptors in cultured rat hippocampal astrocytes. Life Science, 72, 431-442.(2002)

  2. Koizumi, S., Rosa, P., Willars, G.B., Challiss, R.A.J., Taverna, E., Francolini, M., Bootman, M.D., Lipp, P., Inoue, K., Roder, J., Jeromin, A. Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells. J. Biol. Chem., 277, 30315-30324. (2002)

  3. Scalettar, B.A., Rosa, P., Taverna, E., Francolini, M., Tsuboi, T., Terakawa, Koizumi, S., Roder, J. and Jeromin, A. Neuronal calcium sensor-1 binds to regulated secretory organelles and functions in basal and stimulated exocytosis in PC12 cells. J. Cell. Sci., 115, 2399-2412. (2002)

  4. Tsuda, M., Y. Shigemoto-Mogami, Ueno, S., Koizumi, S., H. Ueda, T. Iwanaga and Inoue, K.. Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain. Eur. J. Neurosci., 15, 1444-1450. (2002)

  5. Inoue, K., Koizumi, S., Fuzjiwara S., Denda Inoue, K., M. Denda. Functional vanilloid receptors in cultured normal human epidermal keratinocytes. Biochem. Biophys. Res. Commun., 291, 124-129. (2002)

2001

  1. Shigemoto-Mogami, Y., Koizumi, S., Tsuda, M., Ohsawa, K., Kohsaka, S., Inoue, K. Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J. Neurochem., 78, 1339-1349. (2001)

  2. Tsuda, M., Koizumi, S., Inoue, K. Role of endogenous ATP at the incision area in a rat model of postoperative pain. Neuroreport, 12, 1701-1704.(2001)

  3. Inoue, K., Koizumi, S… Mechanism of the inhibitory action of ATP in rat hippocampus. Drug Development Research, 52, 95-103. (2001)

2000

  1. Tsuda, M., Koizumi, S., Y. Kita, Y. Shigemoto Ueno, S., Inoue, K Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: Involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent. J. Neurosci. 20, RC90 (1-5). (2000)

1999

    • Inoue, K., Koizumi, S., Ueno, S., Kita, A., Tsuda, M. The function of ATP receptors in the synaptic transmission in the hippocampus. In: Progres in Brain Res., P. Illes and H. Zimmermann eds. Amsterdam, Elsevier Science BV. 20, pp193-206.(1999)

  2. Koizumi, S., Bootman, M.D., Bobanociv, L., Scheller, M., Berridge, M.J., Lipp, P. Characterization of elementary Ca2+ release signals in NGF-differentiated PC12 cells and rat hippocampal neurons. Neuron, 22, 125-137. (1999)

  3. Koizumi, S., Lipp, P., Berridge M.J., Bootman, M.D. Regulation of ryanodine receptor opening by luminal Ca2+ undelies quantal Ca2+ release in PC12 cells. J Biol. Chem. 274, 33327-33333. (1999)

1998

    • Inoue, K., Koizumi, S. ATP receptors in psychosis. In: Ca ion modulators; The new wave of psychotropic drugs, Inoue, K. and Y. Watanabe eds. Amsterdam, Harwook Academic Publishers. pp199-213.(1998)
    • Nakazawa, K., Koizumi, S., Ito, K. and Inoue, K. Selective inhibition by fluspirilene and pimozide of L-type Ca2+ channels. In: Ca ion modulators; The new wave of psychotropic drugs, Inoue, K., Y. Watanabe eds. Amsterdam, Harwook Academic Publishers. pp185-198. (1998)

  3. Koizumi, S., Inoue, K.Functional coupling of secretion and capacitative calcium entry in PC12 cells. Biochem. Biophys. Res. Commun., 247, 293-298. (1998)

  4. Ueno, S., Koizumi, S., Inoue, K. Characterization of Ca2+ influx through recombinant P2X receptor in C6BU-1cells, Br.J.Pharmacol. 124, 1484-1490.(1998)

  5. Koizumi, S., H. Uneyama, Ikeda, M., Ueno, S., Inoue, K.. Inhibition by imipramine of ATP-evoked responses in rat pheochromocytoma cells. Biochem. Biophys. Res. Commun. 244, 342-346. (1998)

  6. Inoue, K., Nakajima, Y., Morimoto, T., Kikuchi, S., Koizumi, S., Kohsaka, S.. ATP stimulation of Ca2+-dependent plasminogen release from cultured microglia. Br. J. Phrmacol. 123, 1304-1310. (1998)

  7. Koizumi, S., Inoue, K. Functional coupling of secretion and capacitative calcium entry in PC12 cells. Biochmm. Biophys. Res. Commun. 244, 293-297. (1998)

  8. Koizumi, S., M. Ishiguro, I. Ohsawa, T. Morimoto, C. Takamura, Inoue, K., Kohsaka, S The effect of a secreted form of beta-amyloid-precursor protein on intracellular Ca2+ increase in rat cultured hippocampal neurones. Br. J. Pharmacol. 123, 1483-1489.. (1998)

1997

  1. Shibaguchi, H., Kataoka, Y., Koizumi, S., Kohzuma, M., Obana, M., Himeno, A. Yamashita K., Taniyama, K. Nitric oxide participates in the stimulatory and neurotoxic action of endothelin on rat striatal dopaminergic neurons. Cell. Mol. Neurobiol. 17, 471-481. (1997)

  2. Koizumi, S., Inoue, K. Inhibition by ATP of Ca2+ -oscillation in cultured rat hippocampal neurons. Br. J. Pharmacol. 122, 51-58. (1997)

1996

    • Inoue, K., Koizumi, S., Ueno, S. Implication of ATP receptors in brain function. Progress Neurobiol. 50, 483-492.(1996)
    • Nakazawa, K., Inoue, K., T. Watano, Koizumi, S., , Fujimori, K., Inoue, K. Suppression by zinc of cationic conductance that may underlie facilitation of neurotransmission in rat hippocampal neurons. In: Preclinical and clinical strategies for the tratment of neurodegenerative, cerebrovascular and mental disorders, in: Int. Acad. Drug Res., T. Shibuya ed. Basel, Karger, 11, 102-105. (1996).
    • Koizumi, S., , Ikeda, M., Inoue, K., Nakazawa, K., Ohno, Y., Inoue, K.. Zinc ion potentiates various responses mediated by P2-purinoceptor/channels in rat pheochromocytoma cells. In: Preclinical and clinical strategies for the tratment of neurodegenerative, cerebrovascular and mental disorders, in: Int. Acad. Drug Res., T. Shibuya ed. Basel, Karger, 11, 180-186. (1996)

  4. Ito, K., Nakazawa, K., Koizumi, S., Liu M Takeuchi K, Hashimoto T, Ohno, Y., Inoue, K. Inhibition by antipsychotic drugs of L-type Ca2+ channel current in PC12 cells. Eur J Pharmacol. 314, 143-150. (1996)

  5. Inoue, K., Koizumi, S., Ueno, S.Implication of ATP receptors in brain functions. Prog Neurobiol. 50, 483-492. (1996)

  6. Ikeda, M., Koizumi, S.,Nakazawa, K, Inoue, K., Ito, K., Inoue, K. Potentiation by cadmium ion of ATP-evoked dopamine release in rat phaeochromocytoma cells. Br. J. Pharmacol, 117, 950-954. (1996)

1995

  1. Nakazawa, K., Ito, K., Koizumi, S., Ohno, Y., Inoue, K. Reduction of acetylcholine-activated current by low concentrations of extracellular adenosine 5′-triphosphate. Life Science, 57, PL 351-356.(1995)

  2. Kohno, Y., Takata, M., Koizumi, S., Ohiwa, Y., Kohjimoto, Y..Protective effects of nebracetam on ischemia-induced depletion of energy-rich compounds and catecholamines in rat brain regions. Pharmacometrics, 50, 359-366. (1995)

  3. Nakazawa, K., Ito, K., Koizumi, S., Ohno, Y., Inoue, K  Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cells. Br J. Pharmacol., 116, 2603-2610. (1995)

  4. Koizumi, S., Ikeda, M., Nakazawa, K., Inoue, K., Ito, K., Inoue, K. Inhibition by haloperidol of adenosine 5′-triphosphate-evoked responses in rat pheochromocytoma cells. Biochem. Biophys. Res. Commun, 210, 624-630. (1995)

  5. Koizumi, S., Nakazawa, K., Inoue, K. Inhibition by Zn2+ of UTP-induced Ca2+-influx but not Ca2+-mobilization in rat phaeochromocytoma cells. Br. J. Pharmacol, 115, 1502-1508.(1995)

  6. Koizumi, S., Kataoka, Y., Inoue, K., Kohzuma, M., Niwa, M., Taniyama, K. Contribution of L-typeCa2+ channels to long-termenhancement of high K(+)- evoked release of dopamine from ratstriatalslices. Neurosci. Lett. 187, 123-126. (1995)

  7. Ochi, M., Inoue, H., Koizumi, S., Shibata, S., S. Watanabe. Long-term enhancement of dopamine release by high frequency tetanic stimulation via a N-methyl-D-asparatae-receptor-mediated pathway in rat striatum. Neurosci. 66, 29-36 (1995)

  8. Inoue, K., Koizumi, S., Nakazawa, K. Glutamate-evoked release of adenosine 5′-triphosphate causing an increase in intracellular calcium in hippocampal neurons. NeuroReport, 6, 437-440 (1995)

  9. Nakazawa, K., Inoue, K., Ito, K., Koizumi, S., Inoue, K. Inhibition by suramin and reactive blue 2 of GABA and glutamate receptor channels in rat hippocampal neurons. Naunyn-Schumiedeberg’s Arch. Pharmacol., 351, 202-208.(1995)

  10. Koizumi, S., Ikeda, M., Inoue, K., Nakazawa, K., Inoue, K. Enhancement by zinc of ATP-evoked dopamine release from rat pheochromocytoma PC12 cells. Brain Res., 673, 75-82.(1995)

  11. Kataoka, Y., Koizumi, S., Kohzuma, M., Shibaguchi, H., Shigematsu, K., Niwa, M., Taniyama, K. N-methyl-D-aspartate receptor involvement in endothelin neurotoxicity in rat striatal slices. Eur. J. Pharmacol., 273, 285-289. (1995)

  12. Nakazawa, K., Inoue, K., Watano T, Koizumi, S., Inoue, K. Zinc potentiation of neurotransmission and inhibition of background cationic conductance in rat cultured hippocampal neurones. J. Physiol. (Lond.), 484, 447-462 (1995)

  13. Koizumi, S., Ikeda, M., Nakazawa, K., Nagamatsu, K., Hasegawa, A., Inoue, K.Accentuation by pertussis toxin of the 5-hydroxytryptamine-induced potentiation of ATP-evokedresponses in rat pheochromocytoma cells. Neurosci. Lett. 183, 104-107. (1995)

1994

  1. Inoue, K., Koizumi, S., Nakajima, K., Hamanoue, M., Kohsaka, S.Modulatoryeffect of plasminogen on NMDA-inducedincrease in intracellular free calcium concentration in rat cultured hippocampal neurons. Neurosci. Lett., 179, 87-90 (1994)

  2. Ochi, M., Koizumi, S., Shibata S., Watanabe, S.  A facilitatory role of vasopressin in hypoxia/hypoglycemia-induced impairment of dopamine release form rat striatal slices. Brain Res., 633, 91-96. (1994).

  3. Kohzuma, M., Kataoka, Y., Koizumi, S., . Shibaguchi H, M. N-Nakashima, Yamashita K., Niwa, M. and Taniyama, K.. ETB receptor involvement in stimulatory and neurotoxic action of endothelin on dopamine neurones. NeuroReport, 5, 2653-2656(1994)

  4. Koizumi, S., Inoue, K., Kataoka, Y., Niwa, M., Takanaka, A. Endothelin-3 activates a voltage-gated Ca channel via a pertussis toxin sensitive mechanism leading to dopamine release from PC12 cells. Neurosci. Lett., 166, 191-194 (1994)

  5. Koizumi, S., Kataoka, Y., Niwa, M. Watanabes S., Taniyama, K. Two distinct pathways are involved in the endothelin-3-evoked dopamine release from rat striatal slices. Eur. J. Pharmacol., 259, 195-201 (1994)

  6. Koizumi, S., Kataoka, Y., Niwa, M., Yamashita, K., Taniyama, K., Kudo, Y. Endothelin increased [Ca2+]i in cultured neurones and slices of rat hippocampus. NeuroReport, 5, 1077-1080 (1994)

  7. Kataoka, Y., Koizumi, S., Niwa, M. Shibaguchi H,Shigematsu K, Taniyama, K. Endothelin-3 stimulates inositol 1,4,5-trisphosphate production and Ca2+ influx to produce biphasic dopamine release from rat striatal slices. Cell. Mol. Neurobiol., 14, 271-280.(1994)

  8. Nakazawa, K., Inoue, K., Koizumi, S., Inoue, K.Facilitation by 5-hydroxytryptamine of ATP-activated current in rat pheochromocytoma cells Pflügers Arch., 427, 492-499 (1994)

  9. Inoue, K., Watano, T. Koizumi, S., Nakazawa, K., Burnstock, G. Dual modulation by adenosine of ATP-activated channels through GTP-binding proteins in rat pheochromocytoma PC12 cells. Eur. J. Pharmacol. 268, 223-229.(1994)

  10. Koizumi, S., Watano, T., Nakazawa, K., Inoue, K., (1994) Potentiation by adenosine of ATP-evoked dopamine release via a pertussis toxin-sensitive mechanism in rat phaeochromocytoma PC12 cells. Br J Pharmacol., 112, 992-997.(1994)

  11. Nakazawa, K., Inoue, K., Koizumi, S., Ikeda, M., Inoue, K. Inhibitory effects of capsaicin on acetylcholine-evoked responses in rat pheochromocytoma cells. Br. J. Pharmacol. 113, 296-302 (1994)

1993

  1. Kataoka, Y., Kouzuma, M., Koizumi, S., Niwa, M., Taniyama K. and Fujiwara, M. (1993). Neuroprotective effect of TOKI-SHAKUYAKU-SAN (TJ-23) on hypoglycemia/ hypoxia-induced neuronal damage in rat striatal slices. Phytotherapy Res., 7, S67-S69

  2. Yamashita, K., Kataoka, Y., Niwa, M., Shigematsu, K., Koizumi, S., Taniyama, K. Increased production of endothelins in the hippocampus of stroke-prone spontaneously hypertensive rats following transient forebrain ischemia: Histochemical evidence. Cell. Mol. Neurobiol.13, 15-23 (1993)

1992

  1. Koizumi, S., Kataoka, Y., Niwa, M., Kumakura, K. Endothelin-3 stimulates the release of catecholamine from cortical and striatal slices of the rat. Neurosci. Lett. 134, 219-222.(1992)

  2. Shindou, T., Koizumi, S., Kataoka, Y., Watanabe, S., Yamamoto, K., Nakanishi, H. Inhibitory effect of NMDA on dopaminergic transmission in the slice preparation of rat globus pallidus. Jpn. J. Pharmacol. 58, 79-82.(1992)

  3. Kataoka, Y., Niwa, M., Koizumi, S., Watanabe, S., Kouzuma, M., Taniyama, K. Nebracetam (WEB 1881 FU) prevents N-methyl-D-asparatate receptor-mediated neurotoxity in rat striatal slices. Jpn. J. Pharmacol., 59, 247-250 (1992)

1991

  1. Kataoka, Y., K. Shibata, A. Miyazaki, Y. Inoue, K. Tominaga, Koizumi, S., Ueki, S., Niwa, M. Involvement of the dorsal hippocampus in mediation of the antianxiety action of Tandospirone, a 5-HT1A agonistic anxiolytic. Neuropharmacolgy 30, 475-480 . (1991)

  2. Kataoka, Y., Koizumi, S., Ueki, S., Niwa, M. Is an endothelin a neurotoxic factor in the brain? Neurochem. Int. 18, 503-506 .(1991)

  3. Kataoka, Y., Kouzuma, M., Koizumi, S., Niwa, M., Taniyama, K., Fujiwara, M. Neuroprotective action of TJ-23 (TOKI-SHAKUYAKU-SAN) in the hypoglycemic/hypoxic brain: Patient Benefit and Japanese Kampo Therapy, Oxford Chemical Communications, 21-23 (1991)

1990

  1. Koizumi, S., Kataoka, Y., K. Shigematsu, Niwa, M., S. Ueki. Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neural damage using rat striatal slices. Jpn. J. Pharmacol. 53, 175-183. (1990)

1989

  1. Kataoka, Y., Koizumi, S., K. Kumakura, M. Kurihara, Niwa, M., S. Ueki Endothelin-triggered brain damage under hypoglycemia evidenced by real-time monitoring of dopamine release from rat striatal slices. Neurosci. Lett., 107, 75-80.(1989)

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