Achievement
研究実績

Kubota Y, Shigetomi E, Saito K, Shinozaki Y, Kobayashi K, Tanaka M, Parajuli B, Tanaka KF, Koizumi S. Establishment and Use of Primary Cultured Astrocytes from Alexander Disease Model Mice. Int. J. Mol. Sci. 25(22), 12100; https://doi.org/10.3390/ijms252212100

Shigetomi E, Suzuki H, Hirayama YJ, Sano F, Nagai Y, Yoshihara K, Koga K, Tateoka T, Yoshioka H, Shinozaki Y, Kinouchi, H, Tanaka KF, Bito H, Tsuda M, Koizumi S. Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. Nat Commun, 15(1):6525. doi: 10.1038/s41467-024-50190-7.　【Press Release】【Media report】

2023 US-Japan NVU Workshop Group. From bench to bedside: US-Japan Collaborative Workshop on the NVU. J Physiol Sci. ;74:31. doi: 10.1186/s12576-024-00917-4. (2024)

Parajuli B, Koizumi S. Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia. Purinergic Signalling, https://doi.org/10.1007/s11302-024-10014-1. Online ahead of print. (2024)

Hirayama Y, Le PN H, Hashimoto H, Ishii I, Koizumi S, Anzai N. Preconditioning-induced facilitation of lactate release from astrocytes is essential for brain ischemic tolerance. eNeuro, ENEURO.0494-23.2024; doi: 10.1523/ENEURO.0494-23.2024. Online ahead of print.　(2024)

Dewa K, Arimura N, Kakegawa W, Itoh M, Adachi T, Miyashita S, Inoue U Y, Hizawa K, Hori K, Honjoya N, Yagishita H, Yaya S, Miyazaki T, Usui C, Tatsumoto S, Tsuzuki A, Uetake H, Sakai K, Yamakawa K, Sasaki T, Nagai J, Kawaguchi Y, Sone M, Inoue T, Go Y, Ichinohe N, Kaibuchi K, Watanabe M, Koizumi S, Yuzaki M, Hoshino M. Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation. Nat Commun, 15, 458. https://doi.org/10.1038/s41467-023-44579-z. （2024）

Saito K, Shigetomi E, Shinozaki Y, Kobayashi K, Parajuri B, Kubota Y, Sakai K, Miyakawa M, Horiuchi H, Nabekura J, Koizumi S. Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model. Brain. 147(2): 698-716. doi: 10.1093/brain/awad358. (2024)　【Press Release】【Media report】

Shigetomi E, Sakai K, Koizumi S. Extracellular ATP/adenosine dynamics in the brain and its role in health and disease. Front. Cell Dev. Biol. 11:1343653. doi: 10.3389/fcell.2023.1343653（2024）

Le Y-P, Saito K, Parajuli B, Sakai K, Kubota Y, Miyakawa M, Shinozaki Y, Shigetomi E, Koizumi S. Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms. Int. J. Mol. Sci. 24, 17597. https://doi.org/10.3390/ijms242417597 (2023) 

Ihara T, Shinozaki Y, Shigetomi E, Danjo Y, Tsuchiya S, Kanda M, Kamiyama M, Takeda M, Koizumi S, Mitsui T. G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders. Life Sci. :332:122072. doi: 10.1016/j.lfs.2023.122072.(2023)

Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, Mori Y, Kaneko S, Shirakawa H. The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production. Sci. Adv. 9(29):eadh0102,  doi: 10.1126/sciadv.adh0102. (2023) 

Shinozaki Y, Kashiwagi K, Koizumi S. Astrocyte Immune Functions and Glaucoma. Int J Mol Sci, 24(3):2747. doi: 10.3390/ijms24032747.（2023）

Ono T, Yamashita T, Kano R, Inoue M, Okada S, Kano K, Koizumi S, Iwabuchi K, Hirabayashi Y, Matsuo I, Nakashima Y, Kamiguchi H, Kohro Y, *Tsuda M. GPR55 contributes to neutrophil recruitment and pain induction after spinal cord compression in mice. Brain, Behavior and Immunity, 110 276-287. Doi:10.1016/j.bbi.2023.03.008. (2023) 

Saito K, Koizumi S. A promising drug for neuropathic pain: identification of vesicular nucleotide transporter as a novel target of eicosapentaenoic acid. Purinergic Signal, 19(4):587-589. doi: 10.1007/s11302-022-09918-7. （2023）

Shinozaki Y, Saito K, Kashiwagi K, Koizumi S. Ocular P2 receptors and glaucoma. Neuropharmacology,　222:109302. doi: 10.1016/j.neuropharm.2022.109302.Epub 2022 Oct 30. (2022）

Shinozaki Y, Leung A, Namekata K, Saitoh S, Nguyen HB, Takeda A, Danjo Y, Morizawa YM, Shigetomi E, Sano F, Yoshioka N, Takebayashi H, Ohno N, Segawa T, Miyake K, Kashiwagi K, Harada T, Ohnuma S, Koizumi S. Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy. Sci Adv, 8(44):eabq1081.  doi: 10.1126/sciadv.abq1081. Epub 2022 Nov 4(2022) 【Press Release】

Morizawa YM, Matsumoto M, Nakashima Y, Endo N, Aida T, Ishikane H, Beppu K, Moritoh S, Inada H, Osumi N, Shigetomi E, Koizumi S, Yang G, Hirai H, Tanaka K, Tanaka KF, Ohno N, Fukazawa Y, Matsui K. Synaptic pruning through glial synapse engulfment upon motor learning. Nat Neurosci, 25(11):1458-1469. doi: 10.1038/s41593-022-01184-5. Epub 2022 Nov 1.　(2022) 

Shigetomi E, Koizumi S. The role of astrocytes in behaviors related to emotion and motivation. Neurosci Res;187:21-39,  doi: 10.1016/j.neures.2022.09.015. (2022) 

Parajuli B, Koizumi S. Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased Brain. Neurochem Res, 48(4):1066-1076. doi: 10.1007/s11064-022-03742-6. (2022)

Shimozono K, Nan H, Hata T, Saito K, Kim Y-J, Nagatomo H, Ohtsuka T, Koizumi S and Takiyama Y. Ubap1 knock-in mice reproduced the phenotype of SPG80. J Human Genetics,　67, 679–686, doi: 10.1038/s10038-022-01073-6. (2022)

Manita S, Sgigetomi E, Bito H, Koizumi S, Kitamura K. In Vivo Wide-Field and Two-Photon Calcium Imageng from a Mouse using a Large Cranial Window. J. Vis. Exp, (186), e64224, doi:10.3791/64224 (2022)

Koizumi S, Hirayama Y. Ischemic Tolerance Induced by Glial Cells. Neurochem Res, 47(9):2522-2528. doi: 10.1007/s11064-022-03704-y. （2022）

Takeda I, Yoshihara K, Cheung DL, Kobayashi T, Agetsuma M, Tsuda M, Eto K, Koizumi S, Wake H, Moorhouse AJ and Nabekura J. Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour. Nat Commun, 13(1):4100. doi: 10.1038/s41467-022-31773-8. (2022)

Hirayama Y, Anzai N, Kinouchi, H and *Koizumi S. P2X7 receptors in astrocytes; as a switch for ischemic tolerance. Molecules, 27(12):3655.  (2022)

Parajuli B, Shinozaki Y, Shigetomi E and *Koizumi S. Transplantation of Human Induced Pluripotent Stem Cell-derived Microglia in Immunocompetent Mice Brain via Non-invasive Transnasal Route. J Vis Exp, 183, e63574. (2022) 

Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J and *Koizumi S. Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice. J Exp Med, 219 (4): e20210989.(2022) 【Press Release】【Media report】

Ihara T, Shimura H, Tsuchiya S, Kanda M, Kira S, Sawada N, Takeda M, Mitsui T, Shigetomi E, Shinozaki Y, Koizumi S.  Effects of fatty acid metabolites on nocturia. Sci Rep. 12(1):3050.(2022)

Danjo Y, Shinozaki Y, Natsubori A, Kubota Y, Kashiwagi K, Tanaka KF and *Koizumi S. The Mlc1 promotor directs Müller cell-specific gene expression in the retina. TVST, 11(1), 25. doi: 10.1167/tvst.11.1.25. (2022) 

Koizumi S. Glial Purinergic Signals and Psychiatric Disorders. Front. Cell. Neurosci, 15:822614. doi: 10.3389/fncel.2021.822614. eCollection 2021. (2022)

*Konishi H, *Koizumi S and *Kiyama H. Phagocytic astrocytes: emerging from the shadows of microglia. GLIA,70(6):1009-1026. doi: 10.1002/glia.24145.  (*co-correspondence)(2022) 

Koizumi S, Shigetomi E, Sano F, Saito K, Kim SK, Nabekura J. Abnormal Ca2+ Signals in Reactive Astrocytes as a Common Cause of Brain Diseases. Int.J.Mol. Sci, 23, 149. https://doi.org/10.3390/ijms23010149. (2021)

• Youichi, Shinozaki., Schuichi, Koizumi.Potential roles of astrocytes snd Müller cells in the pathogenesis of glaucoma. Jounal of Pharmacological Sciences, 145(3), 262-267 (2021)

• Koizumi S. Glial pharmacology in Asia & Beyond. Pharmacol Res Perspect.(9):e00881.(2021)

• Takanashi K, Shibata K, Mizuno K, Komatsu R, Koizumi S.Goshajinkigan attenuates paclitaxel-induced neuropathic pain via cortical astrocytes. Pharmacol Res Perspect.(9):e00850. (2021)

• Hamada k, Shinozaki, Y, Namekata, K, Matsumoto, M, Ohno N, Segawa T, Kashiwagi K, Harada T, Koizumi S. Loss of P2Y1 receptor triggers glaucoma-like pathology in mice. Br J Pharmacol. 178(22):4552-4571 (2021) 【Press release】【Media report】

• Tanaka, M., Shigetomi, E., Parajuli, B., Nagatomo, H., Shinozaki, Y., Hirayama, Y., Saito, K., Kubota, Y., Danjo, Y., Lee, JH., Kim, SK., Nabekura, J., Koizumi, S. Adenosine A2B Receptor down-regulates Metabotropic Glutamate Receptor 5 in astrocytes during postnatal development. GLIA, 69(11):2546–2558. (2021)

• #Parajuli B, #Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima, K and *Koizumi S. Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice. GLIA,69(10):2332-2348. #equal contribution .(2021)　【Press release】【Media report】

• Kinoshita M, *Ogawa Y, Hama N, Ujiie I, Hasegawa A, Nakajima S, Nomura T, Adachi J, Sato T, Koizumi S, Shimada S, Fujita Y, Takahashi H, Muzukawa Y, Tomonaga T, Abe R and Kawamura T. Neutrophils initiate and exacerbate Steve-Johnson syndrome and toxic epidermal necrolysis. Science Translational Medicine, 13(600):eaax2398. (2021)

• Okamoto, T, Ogawa Y, Kinoshita M, Ihara, T, Shimada S, Koizumi S and *Kawamura T. Mechanical stretch-induced ATP release from keratinocytes triggers Koebner phenomenon in psoriasis. J Dermatol Sci, 103, 60-62. (2021)

• Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S and *Sawada K. Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues. Sensors and Actuators: B, 335,129686. (2021)

• Hirayama,Y., Anzai, N., Koizumi, S. Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance. GLIA, 69(9)：2100-2110.(2021)

• Sano, F., Shigetomi, E., Shinozaki, Y., Tsuzukiyama, H., Saito, K., Mikoshiba, K., Horiuchi, H., Cheung, DL., Nabekura, J., Sugita, K., Aihara, M., Koizumi, S. Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus, JCI Insight, 6(9): e135391. (2021) 【Press release】【Media report】

• Ihara T, Mitsui T, Shimura H, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Koizumi S. and Takeda, M. Different effect of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice. Life Sci, 278, 119555. (2021)

• Escartin C,Koizumi S, Verkhratsky A et al Reactive astrocyte nomenclature, definitions, and future directions, Nat Neurosci, 24, 312-325. (2021)

• Yoshida, K, Ito M, Sato N, Obayashi K, Yamamoto K, Koizumi S, Tanaka S, Furuta K and Matsuoka I. Extracellular ATP augments antigen-induced murine mast cell degranulation and allergic responses via P2X4 receptor activation.J Immunol, 204, 3077-3085 (2020) .

• Shigetomi, E., Saito, K., Sano, F., Koizumi, S. Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders. Int J Mol Sci. 25;20(4). (2019)

• Nakamura Y, Sasaki T, Mochizuki C, Ishimaru K, Koizumi S, Shinbori H, Suzuki-Inoue K and Nakao A. Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cell. Sci Rep 9, 15958. (2019)

• Ihara, T., Nakamura, Y., Nitsui, T., Tsuchiya, S., Kanda, M., Kira, S., Nakagomi. H., Sawada, N., Kamiyama, M., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Nakao, A., Koizumi, S., Takeda, M. Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Sci Rep, 9(1):10069. (2019)

• Shinozaki, Y., Danjo. Y, Koizumi, S. Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration. J Neurochem, 151(1):64-78 (2019)

• Hayashi-Kato M, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M and Sato K. Hyaluronan synthesis supports glutamate transporter activity. J Neurochem, 150 (3) 249-263. (2019)

• Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A and Hwang GW. Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures. J Tox Sci, 44(7), 471-479. (2019)

• Koizumi, S., Hirayama, Y. and Morizawa, YM New roles of reactive astrocytes in the brain: an organizer of cerebral ischemia. Neurochem. Int. 20(4), 996. (2018)

• Mihara, H., Uchida, K., Koizumi, S., Moriyama, Y. Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium. PloS One, 13(10): e0306276. (2018)

• Takeda, A., Shinozaki, Y., Kashiwagi, K., Ohno, N., Eto, K., Wake, H., Nabekura, J. and *Koizumi, S. Microglia mediate non-cell autonomous cell death of retinal ganglion cells. GLIA, 66(11):2366-2384. (2018)

• Fukumoto, Y., Tanaka, KF., Parajuli, B., Shibata, K., Yoshioka, H., Kanemaru, K., Gachet, C., Ikenaka, K., *Koizumi, S. and *Kinouchi, H. Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury. J Cereb Blood Flow Meta. 39(11):2144-2156. (2018)

• Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M and Koizumi S. The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium. Sci Rep, 8(1):5699. (2018)

• Kinoshita, M., Hirayama, Y., Fujishita, K., Shibata, K., Shinozaki, E., Takeda, A., Le, HPN., Hayashi, H., Hiasa, M., Moriyama, Y., Ikenaka, K., Tanaka, KF., Koizumi, S. (2018) Anti-Depressant Fluoxetine Reveals its Thrapeutic Effect Via Astrocytes. E BioMedicine. 32:72-83

• Ihara, T., Mitsui, T., Nakamura, Y., Kanda, M., Tsuchiya, S., Kira, S., Nakagomi, H., Sawada, N., Kamiyama, M., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Nakao, A., Takeda, M, Koizumi, S. The time-dependent variation of ATP release in mouse primary-cultured urothlial cells is regulated by the clock gene. Neurourol Urodym. 37(8):2535-2543. (2018)

• Shigetomi, E., Hirayama, J, Y., Ikenaka, K., Tanaka, K., Koizumi, S. Role of Purinergic Receptor P2Y1 in spatiotemporal Ca2+ dynamics in astrocytes. J Neurosci. 7 February 2018, 38 (6) 1383-1395 (2018)

• Koizumi, S., Hirayama, Y., Morizawa, YM. New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia. Neurochem Int. [Epub ahead of print](2018)

• Saito, K., Shigetomi, E., Yasuda, R., Sato R., Nakano, M., Tashiro, K., Tanaka, KF., Ikenaka, K., Mikoshiba, K., Mizuta, I., Yoshida, T., Nakagawa, M., Mizuno, T., Koizumi, S. Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an alexander disease model. Glia. 66(5):1053-1067. (2018)

• Hirayama, Y., Koizumi, S. Astrocytes and ischemic tolerance. Neurosci. Res. 126:53-59 (2017)

• Kim, SK., *Nabekura, J. and *Koizumi, S. Astrocyte-mediated synapse remodeling in the pathological brain. GLIA 65(11):1719-1727. (2017)

• Shinozaki, Y., Kashiwagi, K., Namekata, K., Takeda, A., Ohno, N., Robaye, B., Harada, T., Iwata, T., Koizumi, S. Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy. JCI Insight. 2(19). [Epub ahead of print] (2017)

• Ihara, T., Mitsui, T., Nakamura, Y., Kanba, M., Tsuchiya, S., Kira, S., Nakagomi, H., Sawada, N., Hirayama, Y., Shibata, K., Shigetomi, E., Shinozaki, Y., Yoshimura, M., Nakao, A., Takeda, M., Koizumi, S. The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells. Neurourol Urodyn. 37(3):942-951. (2017)

• Katoh, M., Wu, B., Nguyen, HB., Thai, TQ., Yamasaki, R., Lu, H., Rietsch, AM., Zorlu, MM., Shinozaki, Y., Saitoh, Y., Saitoh, S., Sakoh, T., Ikenaka, K., Koizumi, S., Ransohoff, RM., Ohno, N. Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation. Scientific Reports 7, Article number: 4942 (2017)

• Morizawa, Y., Hirayama, Y., Ohno, N., Shibata, S., Shigetomi, E., Sui, Y., Nabekura, J., Sato, K., Okajima, F., Takebayashi, H., Okano, H., Koizumi, S. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun., 8, 28. (2017)

• Kawai, T., Okochi, Y., Ozaki, T., Imura, Y., Koizumi, S., Yamazaki, M., Abe, M., Sakimura, K., Yamashita, T., Okamura, Y. Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production. J Neurochem., 142(5):686-699. (2017)

• Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., Tanaka, KF., Koizumi, S. (2017) Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor downregulation. Cell Reports 2017, 19: 1151-1164

• Kim, SK., Nabekura, J., Koizumi, S. Astrocyte-mediated synapse remodeling in the pathological brain. Glia., ;65(11):1719-1727. (2017)

• Zhang, X., Gao, S., Tanaka, M., Zhang, Z., Huang, Y., Mitsui, T., Kamiyama, M., Koizumi, S., Fan, J., Takeda, M., Yao, J. Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction. J Cell Mol Med., 21(9):1791-1802.(2017)

• Hanai, S., Sukigara, S., Dai, H., Owa, T., Horike, S., Otsuki, T., Saito, T., Nakagawa, E., Ikegaya, N., Kaido, T., Sato, N., Tskahashi, A., Sugai, K., Saito, Y., Sasaki, M., Hoshino, M., Goto, Y., Koizumi, S., Itoh, M. Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay. Am J Pathol., 187(5):1177-1185. (2017)

• Kira, S., Yoshiyama, M., Tsuchiya, S., Shigetomi, E., Miyamoto, T., Nakagomi, H., Shibata, K., Mochizuki, T., Takeda, M., Koizumi, S. P2Y6-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice. Sci Rep., 10;7(1):771. (2017)

• Hirayama, Y., Koizumi, S. Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning. Glia., 65(3):523-530. (2017)

• Ihara, T., Mitsui, T., Nakamura, Y., Kira, S., Nakagomi, H., Sawada, N., Hirayama, Y., Shibata, K., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Andersson, KE., Nakao, A., *Takeda, M. *Koizumi, S. Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. PLoS One., 6;12(1) (2017)

• Shigetomi, E., Patel, S., Khakh, BS. Probing the Complexities of Astrocyte Calcium Signaling. Trends Cell Biol, 26, 300-312 (2016)

Mizuno, K., Shibata, K., Komatsu, R., Omiya, Y., Kase, Y. Koizumi, S. An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy; combination therapy with Goshajinkigan and Busi. Cancer Biol Ther., 17(11):1206-1212. (2016)

• Nakagomi, H., Yoshiyama, M., Mochizuki, T., Miyamoto, T., Komatsu, R., Imura, Y., Morizawa, Y., Hiasa, M., Miyaji, T., Kira, S., Araki, I., Fujishita, K., Shibata, K., Shigetomi, S., Shinozaki, Y., Ichikawa, R., Uneyama, H., Iwatsuki, K., Nomura, M., de Groat, W.C., Moriyama, Y., Takeda, M., Koizumi, S. Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase. Sci Rep., 6:29761. (2016)

• Ihara, T., Mitsui, T., Nakamura, Y., Kira, S., Miyamoto, T., Nakagomi, H., Sawada, N., Hirayama, Y., Shibata, K., Shigetomi, E., Shinozaki, Y., Yoshiyama, M., Andersson, KE., Nakao, A., Takeda, M. Koizumi, S. The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria. Neurourol Urodyn., 36(4):1034-1038.(2016)

• Miyamoto, A., Wake, H., Ishikawa, AW., Eto, K., Shibata, K., Murakoshi, H., Koizumi, S., Moorhouse, AJ., Yoshimura, Y., Nabekura, J. Microglia contact induces synapse formation in developing somatosensory cortex. Nat Commun., 7:12540. (2016)

• Kim, S.K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., Inada, H., Roh, S.E., Kim, S.J., Lee, G., Bae, H., Moorhouse, A.J., Mikoshiba, K., Fukazawa, Y., *Koizumi, S. and *Nabekura, J. Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. *Co-corespondence author.J Clin Invest., 126(5):1983-1997. (2016)

• Hashimoto, R., Hori, K., Owa, T., Miyashita, S., Dewa, K., Masuyama, N., Sakai, K., Hayase, Y., Seto, Y., Inoue, YU., Inoue, T., Ichinohe, N., Kawaguchi, Y., Akiyama, H., Koizumi, S., Hoshino, M. Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mech Dev., 140:25-40. (2016)

• Taguchi, M., Shinozaki, Y., Kashiwagi, K., Shigetomi, E., Robaye, B., Koizumi, S.
  Muller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y6 receptor signals
  J Neurochem., 136(4):741-751. (2016)

• Hirayama, Y., Ikeda-Matsuo, Y., Notomi, S., Enaida, H., Kinouchi, H., Koizumi, S. Astrocyte-Mediated Ischemic Tolerance. J Neurosci., 35:3794-3805. (2015)

• Nghia NA., Hirasawa T., Kasai H., Obata C., Moriishi K., Mochizuki K., Koizumi S., Kubota T.
  Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms.　Eur J Pharmacol., 752:69-77. (2015)

• Narita, K., Sasamoto, S., Koizumi, S., Okazaki, S., Nakamura, H., Inoue, T., Takeda, S. TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport FASEB J., 29(6):2247-2259. (2015)

• Miyamoto, T., Mochizuki, T., Nakagomi, H., Kira, S., Watanabe, M., Takayama, Y., Suzuki, Y., Koizumi, S., Takeda, M., Tominaga, M. Functional role for Piezo1 in stretch-evoked Ca2+ influx and ATP release in urothelial cell cultures. J Biol Chem., 289:16565-16575. (2014)

• Shinozaki, Y., Nomura, M., Iwatsuki, K., Moriyama, Y., Gachet, C., Koizumi, S, Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission. Sci Rep., 4::4329. (2014)

• Sukigara, S., Dai, H., Nabatame, S., Otsuki, T., Hanai, S., Honda, R., Saito, T., Nakagawa, E., Kaido, T., Sato, N., Kaneko, Y., Takahashi, A., Sugai, K., Saito, Y., Sasaki, M., Goto, Y., Koizumi, S., Itoh, M. Expression of Astrocyte-Related Receptors in Cortical Dysplasia With Intractable Epilepsy. J Neuropathol Exp Neurol., 73:798-806. (2014)

• Shinozaki, Y., Tanaka, A., Kasai, N., Torimitsu, K., Sumitomo, K. Ligand-induced structural changes in membrane-reconstituted ion channel observed with atomic force microscopy. Appl. Phys. Express.,7:2. (*corresponding author) (2014)

• Inoue, K., Komatsu, R., Imura, Y., Fujishita, K., Shibata, K., Moriyama, Y. and Koizumi, S.Mechanisms underlying ATP release in human epidermal keratinocytes. J. Invest. Dermatol., 134:1465-1468.（2014）

• Koizumi, S., Ohsawa, K., Inoue, K., Kohsaka, S. Purinergic receptors in microglia -Functional modal shift of microglia mediated by P1 and P2 receptors. Glia, 61, 47-54. (2013)

• Xiaoping Tong, Eiji Shigetomi, Loren L. Looger,and Baljit S. Khakh．Genetically Encoded Calcium Indicators and Astrocyte Calcium Microdomains.Neuroscientist.19,274-291.(2013)

• Chin Y, Kishi, M., Sekino, M., Nakajo, F., Abe, Y., Terazono, Y., Kato, F., Koizumi, S., Gachet, C. and Hisatsune, T. Involvement of glial P2Y1 receptors in cognitive deficit after focal cerebral stroke in a rodent model. J. Neuroinflamm., 10:95. (2013)

• Shigetomi, E., Bushong, EA., Haustein, MD., Tong, X., Jackson-Weaver, O., Kracun, S., Xu, J., Sofroniew, MV., Ellisman, MH., Khakh, BS..Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol., 141(5):633-647. (2013)

• Shigetomi E, Jackson-Weaver O, Huckstepp RT, O’Dell TJ, Khakh BS. TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. J Neurosci., 33(24):10143-10153. (2013)

• Imura, Y., Morizawa, Y., Komatsu, R., Shibata, K., Shinozaki, Y., Kasai,H., Moriishi, K., Moriyama, Y. and Koizumi S. Microglia release ATP by exocytosis. Glia., 61(8):1320-1330. (2013)

• Noguchi, Y., Shinozaki, Y., Fujishita, K., Shibata, K., Imura, Y., Morizawa, Y., Gachet, C. and Koizumi, S. Astrocytes protect neurons against methylmercury via ATP/P2Y1 receptor-mediated pathways in astrocytes. PLoS One., 8(2):e57898. (2013)

• Kinoshita, M., Nasu-Tada, K., Fujishita, K., Sato, K. and Koizumi, S.Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonicP2Y14– receptor-mediated signal(s). Cel Mol Neurobiol., 33(1):47-58. (2013)

• Takata, F., Dohgu, S., Yamauchi, A., Matsumoto, J., Machida, T., Fujishita, K., Shibata, K., Shinozaki, Y., Sato, K., Kataoka, Y. and Koizumi, S. In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.. PLoS One., 8(1):e55166. (2013)

• Koizumi, S., Ohsawa, K., Inoue, K. and Kohsaka, S. Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors. Glia., 61:47-54.（2013）

• Morizawa Y., Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S. Koizumi, S Cell-autonomous enhancement of glutamate-uptake by female astrocytes. Cell Mol Neurobio., 32: 953-956. (2012)

• Terada, N., Saitoh, Y., Saitoh, S., Ohno, N., Fujishita, K., Koizumi, S., Ohno, S.Visualization of ATP with luciferin-luciferase reaction in mouse skeletal muscles using an “in vivo cryotechnique”. Microsc Microanal., 18:1030-1036. (2012)

Suyama, S., Sunabori, T., Kanki, H., Sawamoto, K., Gachet, C., Koizumi, S. and Okano, H. Purinergic signaling promotes proliferation of adult mouse subventricular zone cells. J. Neurosci., 32: 9238-9247. (2012)

Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J. Clin. Invest., 122:722-732. (2012)

• Koizumi, S. A new role of astrocytes. Japanese Journal of Neurosurgery, 20, 552-558. (2011)

• Chi, Y., Li, K., Yan, Q., Koizumi, S., Shi, L., Takahashi, S., Zhu, Y., Matsue, H., Takeda, M., Kitamura, M. and Yao, J. Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J. Pharmacol. Exp. Ther., 339(1):257-266. (2011)

• Shinozaki, Y., Sumitomo, K., Tanaka, A., Kasai, N., Torimitsu, K. Examination of ion channel protein orientation in supported lipid bilayers. Appl. Phys. Express., 4;10 (2011)

• Shibata, K., Sugawara, T., Fujishita, K., Shinozaki, Y., Matsukawa, T., Suzuki, T. and Koizumi, S. The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice. PLoS One., 6(8):e23510. (2011)

• Koizumi, S. Synchronized Ca2+ oscillations in astrocytes. FEBS J. 277, 286-292.(2010) .

• Inoue, K., Koizumi, S., Kataoka, A., Tozaki-Saito, H. Tsuda, M. P2Y6-evoked microglial phagocytosis.International Review of Neurobiology, 85, 159-163. (2009)

• Shinozaki, Y., Sumitomo, K., Tsuda, M., Koizumi, S., Inoue, K. and Torimitsu, K. Direct observation of ATP-induced conformational changes in single P2X4 receptors. PLoS Biol.,7(5):e1000103. (2009)

• Fujishita, K., Ozawa, T., Shibata, K., Tanabe, S., Sato, Y., Hisamoto, M., Okuda, T. and Koizumi, S. Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. Cell Mol Neurobiol., 29(8):1121-1129. (2009)

• Mochizuki, T., Tokabe, T., Araki, I., Fujishita, K., Shibasaki, K., Uchida, K., Naruse, K., Koizumi, S., Takeda, M. and Tominaga, M. The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J. Bio. Chem., 284(32):21257-21264. (2009)

• Tsuda, M., Toyomitsu T., Komatsu T. Masuda T., Kunifusa E., Nasu-Tada K., Koizumi S., Yamamoto K., Ando J. and Inoue, K. Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury. Glia., 56(5):579-585. (2008)

• Inoue K, Koizumi S, Tsuda M. The role of nucleotides in the neuron-glia communication responsible for the brain functions. J Neurochem. , 102, 1447-1458 (2007).

Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Tozaki-Saitoh, H., Yoshimura, M., Koizumi, S., Shimizu, T., Inoue, K. Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. J. Neurochem., 102(5):1658-1668. (2007)

• Shinozaki, Y., Sato, Y., Koizumi, S., Ohno, Y., Nagao, T., Inoue, K. Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase. Neurosci., 147(1):153-163. (2007)

Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B.V., Jacobson, K.A., Kohsaka, S., Inoue, K. UDP acting at P2Y6 receptors is a novel mediator of microglial phagocytosis. Nature., 446(7139):1091-1095. (2007)